Clemson University Institute for Human Genetics · Greenwood, SC
Buen Abad Lab
Computational RNA biology · Genomics · Multi-omics
The Buen Abad lab develops computational and statistical methods to understand how RNA processing, such as alternative splicing and polyadenylation, shapes gene expression, function, and human disease. We work across scales, from single cells to population-scale genomics, integrating transcriptomic, genomic, and multi-omic data to uncover the regulatory logic of the transcriptome and its role in health and disease.
We are part of the Clemson University Institute for Human Genetics in Greenwood, South Carolina, and are affiliated with the Department of Genetics and Biochemistry.
Research focus
RNA splicing & unproductive transcripts
An often overlooked aspect of alternative splicing is the generation of defective transcripts that are degraded through nonsense mediated decay (NMD). This "unproductive splicing" shapes gene expression and links genetic variation to complex traits and disease.
Single-cell & multi-omics
We develop statistical methods to detect cell-state-associated splicing and coregulation from single-cell data, and to integrate transcriptomic, genomic, and epigenomic data across scales.
Statistical genomics & method development
We build reference-free, interpretable computational models to uncover novel transcript structures in large-scale RNA-seq and multi-omics datasets.